Single Particle Imaging of Polarized Hepatoma Organoids upon Hepatitis C Virus Infection Reveals an Ordered and Sequential Entry Process
نویسندگان
چکیده
منابع مشابه
Polarization restricts hepatitis C virus entry into HepG2 hepatoma cells.
The primary reservoir for hepatitis C virus (HCV) replication is believed to be hepatocytes, which are highly polarized with tight junctions (TJ) separating their basolateral and apical domains. HepG2 cells develop polarity over time, resulting in the formation and remodeling of bile canalicular (BC) structures. HepG2 cells expressing CD81 provide a model system to study the effects of hepatic ...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2018
ISSN: 1931-3128
DOI: 10.1016/j.chom.2018.02.005